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AZ7550 hydrochloride

CAS No. 2309762-40-9

AZ7550 hydrochloride ( AZ7550 hydrochloride (1421373-99-0 free base) )

Catalog No. M26549 CAS No. 2309762-40-9

AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ7550 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
  • Description
    AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).(In Vitro):AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).
  • Synonyms
    AZ7550 hydrochloride (1421373-99-0 free base)
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    Bacterial; GABAA; Human Endogenous Metabolite; Virus Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2309762-40-9
  • Formula Weight
    522.0
  • Molecular Formula
    C27H32ClN7O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539.
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