AZ7550 hydrochloride
CAS No. 2309762-40-9
AZ7550 hydrochloride( AZ7550 hydrochloride (1421373-99-0 free base) )
Catalog No. M26549 CAS No. 2309762-40-9
AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 231 | Get Quote |
|
10MG | 357 | Get Quote |
|
25MG | 597 | Get Quote |
|
50MG | 851 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAZ7550 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
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DescriptionAZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).(In Vitro):AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).
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In VitroAZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
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In Vivo——
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SynonymsAZ7550 hydrochloride (1421373-99-0 free base)
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PathwayAngiogenesis
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TargetEGFR
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RecptorBacterial| GABAA| Human Endogenous Metabolite| Virus Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number2309762-40-9
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Formula Weight522.04
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Molecular FormulaC27H32ClN7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 1.88 mg/mL (3.60 mM)
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SMILESC=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yang H, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539.
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